What is Spravato® (esketamine)?

Spravato® (esketamine) is a nasal spray available for patients with TRD or MDD who have not responded to traditional therapies. It works by targeting the glutamate system to enhance brain plasticity and neural connectivity. SPRAVATO® is administered in our REMS- certified clinic under direct medical supervision, with patients monitored for at least two hours post-dose. Treatment follows a phased protocol: the induction phase (Weeks 1–4) involves twice-weekly sessions, followed by the optimization phase (Weeks 5–8) with once- weekly sessions, and the maintenance phase (Week 9 onward) with treatments every one to four weeks based on individual needs.

Our office does everything we can to provide patients with clear information about the financial aspects of Spravato treatment, including how to access available savings programs. While we don’t handle or bill for the cost of the medication itself, that is managed by your pharmacy, we always advocate for patients to get the lowest cost possible. This is why we strongly encourage participation in both the Spravato Savings Program and the Observation Rebate Program.