Spravato® (esketamine)
What is Spravato® (esketamine)?
Spravato® (esketamine) is a nasal spray available for patients with TRD or MDD who have not responded to traditional therapies. It works by targeting the glutamate system to enhance brain plasticity and neural connectivity. SPRAVATO® is administered in our REMS- certified clinic under direct medical supervision, with patients monitored for at least two hours post-dose. Treatment follows a phased protocol: the induction phase (Weeks 1–4) involves twice-weekly sessions, followed by the optimization phase (Weeks 5–8) with once- weekly sessions, and the maintenance phase (Week 9 onward) with treatments every one to four weeks based on individual needs.
Our office does everything we can to provide patients with clear information about the financial aspects of Spravato treatment, including how to access available savings programs. While we don’t handle or bill for the cost of the medication itself, that is managed by your pharmacy, we always advocate for patients to get the lowest cost possible. This is why we strongly encourage participation in both the Spravato Savings Program and the Observation Rebate Program.
FAQs
How long does it take to start Spravato?
From your initial evaluation to your first Spravato session, the process typically takes 3–4 weeks. This timeline allows for completing enrollment in the Spravato REMS program, obtaining insurance authorization, and scheduling delivery of the medication.
Can I take Spravato at home?
No. Spravato (esketamine) is delivered directly to our office and must be administered under medical supervision. Patients are monitored in the office for at least two hours after treatment due to the risk of potential side effects such as sedation, dissociation, or respiratory depression.
How do I take Spravato?
Spravato (esketamine) is a prescription nasal spray administered by the patient under the direct supervision of a healthcare professional at a certified treatment center.
Can I drive after Spravato?
No, you cannot drive after a Spravato treatment session. Due to potential side effects like sedation, dizziness, and dissociation, it is a mandatory safety requirement that you do not operate a vehicle or machinery on the day of your treatment.
Do I pay a copay for both the office visit and the medication?
Our office only collects the office visit copay (if applicable). All medication costs are handled directly between you and your pharmacy.
Can I pay out of pocket for Spravato?
No. Spravato (esketamine) treatment is only offered to patients with active insurance coverage.
Is Central California TMS Center a REMS Certified Treatment Center?
Yes! REMS certification means our clinic meets FDA requirements to safely administer medications that have a Risk Evaluation and Mitigation Strategy (REMS). This certification requires specific training and authorization for healthcare professionals to prescribe and administer certain higher-risk medications, ensuring patient safety and proper monitoring. Central California TMS Center is fully REMS-certified and FDA-authorized to provide this treatment safely.